Table 1 Participant characteristics.

From: The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method

Subject ID/category

Age range

Gender

ApoE

CSF Aβ42/40

MCBP

Converter on

follow-up MCBP?

Amyloid status during labeling study

CDR

Clinical diagnoses

1: AD Amyloid Converter

60–65

M

3/3

0.122

0.05

Y

A− (PET);

A+ (CSF-borderline)

1

DAT (9 years of clinical history)

2: AD Amyloid [+]

85–90

M

3/3

0.084

N/A

N/A

A+ (CSF)

(PET data unavailable)

0.5

DAT w/CVD not contributing; remote CVD (3 years of clinical history)

3: AD Amyloid [−]

65–70

F

3/3

0.208

0.01

N/A

A− (PET); A− (CSF)

0

No dementia; remote mood disorder (8 years of clinical history)

4: AD Amyloid [−]

70–75

M

3/3

0.142

0.11

N/A

A− (PET); A− (CSF)

0

No dementia

5: AD Amyloid [−]

65–70

F

3/3

0.200

0.04

N

A− (PET); A− (CSF)

0

No dementia

6: AD Amyloid [−]

60–65

M

3/3

0.165

0.05

N/A

A− (PET); A− (CSF)

0

Cognitively normal

7: AD Amyloid [−]

65–70

F

2/3

0.203

0.08

N/A

A− (PET); A− (CSF)

0

Cognitively normal

  1. MCBP score < 0.18 or CSF Aβ42/Aβ40 ratio > 0.12 is classified as Amyloid [−].
  2.  amyloid-beta, AD Alzheimer's disease, ApoE apolipoprotein E, CSF cerebrospinal fluid, MCBP mean cortical binding potential score by PET PIB, PET positron emission tomography, CDR clinical dementia rating, DAT Dementia of the Alzheimer type, CVD cerebrovascular disease.