Table 1 Associations of phenotypes (*) FIT + , low- and high-risk CRA, and CRC with independent variables—sex, diabetes, body mass index (BMI), and antibiotics (ABX) in previous year.

From: Reusing a prepaid health plan’s fecal immunochemical tests for microbiome associations with colorectal adenoma

Variables:	Female	Male	BMI < 25	BMI 25–29.9	BMI 30 +	No diabetes	Diabetes	ABX^b = 0	ABX^b 1–10d	ABX^b > 10d
Total	246	292	174	161	203	395	143	336	115	87
FIT− (n)	40	23	16	20	21	47	16	43	13	7
FIT+* (n)	206	269	109	141	182	348	127	293	102	80
Odds ratio	Ref	2.27	Ref	1.03	1.27	Ref	1.07	Ref	1.15	1.68
95% CI		1.28–4.10		0.48–2.21	0.59–2.68		0.57–2.10		0.58–2.43	0.71–4.58
P-value		< 0.05		1.00	0.59		0.88		0.75	0.26
FIT-/CRA- ^a(n)	179	173	90	98	130	256	96	225	70	57
CRA low risk* (n)	37	70	23	35	48	75	32	57	27	23
Odds ratio	Ref	1.95	Ref	1.39	1.44	Ref	1.14	Ref	1.52	1.59
95% CI		1.22–3.16		0.76–2.54	0.82–2.54		0.68–1.87		0.86–2.66	0.86–2.89
P-value		< 0.05		0.27	0.20		0.62		0.12	0.13
FIT-/CRA-/CRA low risk (n)	216	243	113	133	178	338	129	289	97	81
CRA high risk*(n)	28	43	18	26	23	57	14	47	18	6
Odds ratio	Ref	1.36	Ref	1.23	0.81	Ref	0.64	Ref	1.14	0.46
95% CI		0.81–2.27		0.64–2.35	0.41–1.56		0.43–1.22		0.59–2.12	0.15–1.12
P-value		0.23		0.53	0.54		0.19		0.65	0.10
FIT-/CRA- (n)	179	173	90	98	130	263	97	232	70	58
All CRA* (n)	67	119	45	63	73	132	46	104	45	29
Odds ratio	Ref	1.83	Ref	1.24	1.12	Ref	0.94	Ref	1.43	1.12
95% CI		1.27–2.64		0.77–2.01	0.71–1.78		0.61–1.45		0.90–2.27	0.65–1.89
P-value		< 0.01		0.37	0.62		0.84		0.11	0.70
FIT-/CRA-/CRC- (n)	244	286	131	159	201	388	142	329	115	86
CRC* (n)	2	6	4	2	2	7	1	7	0	1
Odds ratio	Ref	2.56	Ref	0.41	0.42	Ref	0.39	Ref	0	0.55
95% CI		0.45–25		0.07–2.28	0.04–3.00		0–3.09		0–2.02	0.01–4.35
P-value	–	0.30		0.29	0.42		0.69		0.20	1.00
FIT-/CRA-(n)	179	173	90	98	130	256	96	225	70	57
CRA/CRC* (n)	67	119	45	63	73	139	47	111	45	30
Odds ratio	Ref	1.84	Ref	1.28	1.12	Ref	0.90	Ref	1.30	1.07
95% CI		1.26–2.69		0.79–2.07	0.71–1.78		0.59–1.38		0.82–2.06	0.62–1.80
P-value		< 0.01		0.30	0.62		0.682		0.26	0.80

Significant associations are highlighted in bold.
^aControl group for CRA and CRC cases: FIT + without CRA or CRC, plus FIT-negatives.
^bABX: antibiotics use.

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Table 1 Associations of phenotypes (*) FIT + , low- and high-risk CRA, and CRC with independent variables—sex, diabetes, body mass index (BMI), and antibiotics (ABX) in previous year.

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