Table 1 In vitro α-glucosidase inhibitory activities of compounds 8a–p.
| ||
|---|---|---|
Compound | Ar | IC50 (µM) |
8a | Phenyl | 70.6 ± 6.8 |
8b | 4-Methylphenyl | 101.6 ± 5.6 |
8c | 4-Methoxyphenyl | 110.0 ± 5.5 |
8d | 3,4,5-Trimethoxyphenyl | 750 < |
8e | 3-Phenoxyphenyl | 127.3 ± 6.5 |
8f | 3-Hydroxyphenyl | 181.4 ± 8.5 |
8g | 4-Hydroxy-3-methoxyphenyl | 287.1 ± 7.4 |
8h | 2-Fluorophenyl | 69.0 ± 4.0 |
8i | 3-Fluorophenyl | 88.1 ± 6.0 |
8j | 4-Fluorophenyl | 84.1 ± 4.5 |
8k | 2-Chlorophenyl | 90.0 ± 7.5 |
8l | 4-Chlorophenyl | 103.4 ± 5.5 |
8m | 3-Bromophenyl | 97.0 ± 4.4 |
8n | 4-Nitrophenyl | 112.4 ± 5.7 |
8o | 6-Nitrobenzo[d][1,3]dioxol-5-yl | 123.3 ± 6.1 |
8p | Thiophen-2-yl | 60.1 ± 3.6 |
Acarbose | – | 750.0 ± 10.5 |
