Table 1 Plasma lipid parameters.

From: Dietary 7-ketocholesterol exacerbates myocardial ischemia–reperfusion injury in mice through monocyte/macrophage-mediated inflammation

Lipid profiles

 

ND

(N = 6)

WD

(N = 6)

7KWD

(N = 6)

Total cholesterol (mg/dL)

93 ± 5

160 ± 4***

150 ± 8***

LDL cholesterol (mg/dL)

20 ± 1

37 ± 2***

36 ± 1***

HDL cholesterol (mg/dL)

54 ± 2

41 ± 3**

44 ± 2*

Triglyceride (mg/dL)

84 ± 8

23 ± 1***

27 ± 4***

Oxysterols

 

ND

(N = 8)

WD

(N = 8)

7KWD

(N = 8)

7α-hydroxycholesterol

8.9 ± 3.7

41.1 ± 15.1

17.3 ± 6.4

7β-hydroxycholesterol

54.0 ± 20.1

149.8 ± 29.9

1168.0 ± 241.6***††

7-ketocholesterol

64.5 ± 12.5

144.7 ± 31.7

399.4 ± 61.9***††

5β,6β-epoxycholesterol

14.3 ± 8.5

43.5 ± 11.6

31.2 ± 6.4

4β-hydroxycholesterol

79.0 ± 9.6

385.6 ± 69.2**

457.7 ± 77.4***

cholestan-3β,5α,6β-triol

0.1 ± 0.0

0.3 ± 0.1

0.3 ± 0.2

24-hydroxycholesterol

3.9 ± 1.3

11.6 ± 3.3

25.6 ± 4.4***†

25-hydroxycholesterol

18.3 ± 5.2

13.6 ± 3.0

17.5 ± 2.9

27-hydroxycholesterol

22.3 ± 6.2

53.1 ± 11.0*

56.3 ± 6.1*

Total oxysterols

480 ± 61

1067 ± 113

2391 ± 299***††

  1. Cholesterol and triglyceride levels are shown in mg/dL. The level of each oxysterol component is shown in ng/mL. Data are expressed as the mean ± SEM and were compared using one-way ANOVA with the post hoc Tukey HSD test. *p < 0.05, **p < 0.01, and ***p < 0.001 versus the ND group. †p < 0.05, and ††p < 0.001 versus the WD group. ND, normal laboratory diet; WD, Western diet; 7KWD, WD containing 7-KC.
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