Table 2 General characteristics of subjects according to CETP genotype in HEXA and KNHANES.

From: The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type

 

CETP

p value

CC

CT

TT

HEXA

Subject (n, %)

20,523(38.3)

25,225(47.1)

7,857(14.7)

 

Age (years)

53.8 ± 8.0

53.8 ± 8.0

53.9 ± 8.0

0.8017

Sex (male)

7,122(34.7)

8,698(34.5)

2.662(33.9)

0.4276

Systolic blood pressure (mmHg)

122.5 ± 14.8

122.4 ± 14.8

122.5 ± 14.7

0.6488

Diastolic blood pressure (mmHg)

75.8 ± 9.7

75.8 ± 9.7

75.8 ± 9.8

0.6183

Fasting glucose (mg/dL)

95.0 ± 19.8

94.9 ± 19.7

94.9 ± 18.5

0.8042

Total cholesterol (mg/dL)

196.1 ± 35.5

197.7 ± 35.8

200.0 ± 35.9

 < 0.0001

HDL-cholesterol (mg/dL)

52.2 ± 12.6

54.3 ± 13.2

56.4 ± 13.8

 < 0.0001

LDL-cholesterol (mg/dL)

119.3 ± 32.0

119.3 ± 32.3

119.6 ± 32.1

0.6610

Triglycerides (mg/dL)

126.9 ± 86.5

124.2 ± 85.1

123.2 ± 84.4

0.0004

AST (IU/L)

23.9 ± 33.2

23.7 ± 13.8

23.6 ± 13.3

0.5443

ALT (IU/L)

22.6 ± 29.3

22.3 ± 17.2

22.3 ± 18.8

0.3703

Alcohol consumption (Drinker, %)

9,051(44.1)

11.218(44.8)

3,482(44.3)

0.2054

KNHANES

Subject (n, %)

5,802(38.9)

6,949(46.5)

2,180(14.6)

 

Age (years)

46.5 ± 16.9

46.7 ± 16.8

46.4 ± 16.6

0.6785

Sex (male)

2,783(48.0)

3,450(50.0)

1,048(48.1)

0.1310

Systolic blood pressure (mmHg)

117.5 ± 16.5

117.7 ± 16.3

117.6 ± 15.9

0.7698

Diastolic blood pressure (mmHg)

75.2 ± 10.6

75.3 ± 10.5

75.4 ± 10.6

0.6617

Fasting glucose (mg/dL)

98.5 ± 22.2

98.5 ± 22.0

98.8 ± 22.5

0.8674

Total cholesterol (mg/dL)

185.8 ± 36.1

188.6 ± 36.3

191.4 ± 35.9

 < 0.0001

HDL-cholesterol (mg/dL)

49.3 ± 11.9

50.9 ± 12.3

52.7 ± 12.3

 < 0.0001

LDL-cholesterol (mg/dL)

115.0 ± 33.7

119.2 ± 34.1

118.5 ± 33.8

 < 0.0001

Triglycerides (mg/dL)

135.2 ± 114.1

134.9 ± 107.3

137.0 ± 115.8

0.7352

AST (IU/L)

22.7 ± 15.8

22.3 ± 11.6

22.3 ± 10.7

0.1381

ALT (IU/L)

22.2 ± 22.9

21.6 ± 16.8

22.0 ± 17.3

0.2100

Alcohol consumption (Drinker, %)

3,842(66.2)

4,654(67.0)

1,432(65.7)

0.4605

  1. All data except alcohol consumption and sex are represented as means ± standard deviation. General linear models and chi-square tests were used to determine differences between CETP genotype.
  2. HDL high-density lipoprotein, AST aspartate aminotransferase, ALT alanine aminotransferase.