Table 3 Association between alcohol consumption and cholesterol (HDL and total) according to CETP genotype.

From: The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type

 

CETP

p value1

CC

CT

TT

HEXA

HDL-cholesterol

Total

Non-drinker

52.2 ± 12.3

54.3 ± 12.8

56.4 ± 13.4

 < 0.0001

Drinker

52.5 ± 13.0

54.8 ± 13.7

56.7 ± 14.1

 < 0.0001

p value2

0.0468

0.0156

0.3931

 

Men

Non-drinker

44.9 ± 10.2

46.7 ± 11.0

48.4 ± 11.2

 < 0.0001

Drinker

48.6 ± 11.4

51.1 ± 12.4

53.0 ± 12.7

 < 0.0001

p value2

 < 0.0001

 < 0.0001

 < 0.0001

 

Women

Non-drinker

53.4 ± 12.2

55.5 ± 12.6

57.6 ± 13.3

 < 0.0001

Drinker

57.4 ± 13.2

59.4 ± 13.8

61.2 ± 14.5

 < 0.0001

p value2

 < 0.0001

 < 0.0001

 < 0.0001

 

Total cholesterol

Total

Non-drinker

197.3 ± 35.7

199.0 ± 36.1

201.3 ± 35.9

 < 0.0001

Drinker

195.3 ± 34.9

197.1 ± 35.2

198.8 ± 35.8

 < 0.0001

p value2

 < 0.0001

 < 0.0001

0.0026

 

Men

Non-drinker

187.3 ± 35.0

190.1 ± 35.6

193.3 ± 34.5

0.0017

Drinker

192.1 ± 34.0

194.6 ± 34.4

197.4 ± 35.7

 < 0.0001

p value2

 < 0.0001

 < 0.0001

0.0159

 

Women

Non-drinker

199.0 ± 35.5

200.4 ± 36.0

202.6 ± 35.9

 < 0.0001

Drinker

199.3 ± 35.6

200.3 ± 36.0

200.6 ± 35.9

0.2872

p value2

0.7260

0.8584

0.0659

 

KNHANES

HDL-cholesterol

Total

Non-drinker

48.3 ± 11.2

50.2 ± 11.6

52.7 ± 11.7

 < 0.0001

Drinker

48.0 ± 12.1

49.8 ± 12.4

51.3 ± 12.7

 < 0.0001

p value2

0.5259

0.3307

0.0548

 

Men

Non-drinker

41.9 ± 8.8

45.0 ± 10.1

47.2 ± 9.3

0.0342

Drinker

45.5 ± 11.0

47.4 ± 11.7

49.6 ± 12.2

 < 0.0001

p value2

0.0053

0.0366

0.3846

 

Women

Non-drinker

47.5 ± 10.2

50.0 ± 53.7

53.7 ± 10.1

 < 0.0001

Drinker

51.4 ± 12.3

53.0 ± 12.3

53.6 ± 12.9

 < 0.0001

p value2

 < 0.0001

 < 0.0001

0.9451

 

Total cholesterol

Total

Non-drinker

189.4 ± 33.6

191.0 ± 33.9

198.7 ± 34.8

 < 0.0001

Drinker

189.9 ± 34.4

192.5 ± 35.0

193.9 ± 33.7

0.0025

p value2

0.7471

0.2212

0.0227

 

Men

Non-drinker

184.4 ± 35.1

184.9 ± 30.0

187.6 ± 27.5

0.9300

Drinker

184.1 ± 32.4

186.1 ± 32.1

188.9 ± 27.9

0.0078

p value2

0.9541

0.7186

0.8351

 

Women

Non-drinker

189.7 ± 34.2

197.2 ± 36.9

207.3 ± 37.8

 < 0.0001

Drinker

195.8 ± 34.9

197.6 ± 35.9

198.9 ± 37.4

0.1620

p value2

0.0043

0.8190

0.0205

 
  1. Data are expressed as means ± standard deviations.
  2. 1General linear models were used to assess differences in variables between CETP genotype.
  3. 2Student’s t-test was used to assess difference in a variable between alcohol consumption in each CETP genotype.
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