Table 4 Effects of CETP genotype and alcohol consumption on HDL-cholesterol according to ALDH2 genotype.

From: The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type

 

ALDH2(GG)

ALDH2(GA + AA)

p value1

Non-drinker

Drinker

Non-drinker

Drinker

HEXA

Total

CC

52.7 ± 12.5

53.0 ± 13.1

51.5 ± 12.0

50.1 ± 12.0

 < 0.0001

CT

55.0 ± 12.8

55.2 ± 13.7

53.4 ± 12.7

52.4 ± 12.9

 < 0.0001

TT

57.0 ± 13.3

57.0 ± 14.3

55.6 ± 13.6

54.9 ± 13.1

 < 0.0001

p value2

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 

Men

CC

45.6 ± 11.1

49.0 ± 11.5

44.6 ± 9.7

47.2 ± 10.6

 < 0.0001

CT

47.9 ± 11.6

51.4 ± 12.5

46.0 ± 10.6

49.6 ± 11.5

 < 0.0001

TT

49.6 ± 12.5

53.2 ± 12.8

47.9 ± 10.5

52.3 ± 12.5

 < 0.0001

p value

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 

Women

CC

53.3 ± 12.5

57.5 ± 13.3

53.5 ± 11.8

56.7 ± 12.5

 < 0.0001

CT

55.6 ± 12.7

59.5 ± 13.8

55.4 ± 12.4

58.9 ± 13.6

 < 0.0001

TT

57.6 ± 13.2

61.3 ± 14.7

57.8 ± 13.6

60.9 ± 12.7

 < 0.0001

p value

 < 0.0001

 < 0.0001

 < 0.0001

0.0006

 

KNHANES

Total

CC

46.6 ± 9.9

49.0 ± 12.3

46.3 ± 10.5

46.4 ± 11.1

 < 0.0001

CT

49.3 ± 11.1

50.6 ± 12.4

48.8 ± 11.1

48.4 ± 11.9

 < 0.0001

TT

53.1 ± 11.2

52.1 ± 12.7

52.7 ± 9.4

50.0 ± 12.7

0.0566

p value

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 

Men

CC

39.9 ± 11.1

46.4 ± 11.4

42.2 ± 8.4

43.5 ± 9.7

 < 0.0001

CT

46.7 ± 11.1

48.4 ± 11.9

44.3 ± 9.8

44.9 ± 10.7

 < 0.0001

TT

50.5 ± 5.4

50.5 ± 12.4

46.4 ± 10.0

47.3 ± 11.4

0.0239

p value

0.1561

 < 0.0001

0.1883

0.0002

 

Women

CC

47.1 ± 9.7

51.8 ± 12.5

48.0 ± 10.7

50.3 ± 11.6

 < 0.0001

CT

49.7 ± 11.1

53.0 ± 12.4

50.4 ± 11.2

53.2 ± 11.8

0.0002

TT

53.2 ± 11.4

53.7 ± 12.7

54.2 ± 8.7

53.3 ± 13.3

0.9532

p value

0.0003

0.0090

0.0003

0.0018

 
  1. Data are expressed as means ± standard deviations.
  2. 1General linear models by CETP genotypes in each group, and differences between alcohol consumption and ALDH2 genotype.
  3. 2General linear models were used to assess CETP genotype differences in variables between alcohol consumption and HDL-cholesterol by ALDH2 genotype.
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