Table 5 Effects of CETP genotype and alcohol consumption on total cholesterol according to ALDH2 genotype.

From: The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type

 

ALDH2(GG)

ALDH2(GA + AA)

p value1

Non-drinker

Drinker

Non-drinker

Drinker

HEXA

Total

CC

197.3 ± 35.5

195.7 ± 35.0

197.2 ± 35.9

193.2 ± 34.4

 < 0.0001

CT

199.3 ± 36.4

197.6 ± 35.2

201.7 ± 35.8

200.3 ± 34.2

 < 0.0001

TT

201.1 ± 35.9

198.5 ± 36.2

201.7 ± 35.8

200.3 ± 34.2

0.0121

p value2)

 < 0.0001

0.0001

 < 0.0001

0.0002

 

Men

CC

185.0 ± 34.0

192.7 ± 34.4

188.5 ± 35.5

190.1 ± 32.4

 < 0.0001

CT

188.1 ± 35.2

194.8 ± 34.5

191.2 ± 35.7

193.9 ± 34.2

 < 0.0001

TT

189.2 ± 31.6

196.5 ± 36.1

195.1 ± 35.6

200.9 ± 33.8

0.0031

p value2)

0.2019

0.0004

0.0069

 < 0.0001

 

Women

CC

198.5 ± 35.4

199.1 ± 35.4

199.8 ± 35.6

200.0 ± 37.7

0.3288

CT

200.3 ± 36.3

200.7 ± 35.8

200.6 ± 35.3

196.8 ± 37.0

0.1015

TT

202.0 ± 36.0

200.7 ± 36.1

203.5 ± 35.7

199.0 ± 35.2

0.1479

p value2

0.0002

0.1065

0.0057

0.3711

 

KNHANES

Total

CC

189.0 ± 35.2

189.5 ± 34.4

188.6 ± 33.8

190.8 ± 33.6

0.7448

CT

195.8 ± 36.4

191.1 ± 34.0

193.9 ± 35.6

193.2 ± 35.8

0.0959

TT

199.0 ± 35.2

192.8 ± 34.2

210.1 ± 38.4

197.3 ± 31.1

 < 0.0001

p value2

0.0738

0.0477

 < 0.0001

0.0209

 

Men

CC

173.3 ± 29.3

182.8 ± 31.4

185.9 ± 35.8

187.2 ± 34.3

0.0641

CT

181.1 ± 32.7

184.7 ± 30.5

186.2 ± 29.2

189.4 ± 35.2

0.0304

TT

185.0 ± 38.4

186.4 ± 28.7

188.3 ± 25.5

195.3 ± 24.4

0.0125

p value2

0.7811

0.0983

0.9691

0.0437

 

Women

CC

189.9 ± 35.4

196.0 ± 35.8

189.6 ± 33.1

195.6 ± 32.1

0.0400

CT

197.8 ± 36.5

197.4 ± 36.0

196.5 ± 37.3

198.4 ± 35.9

0.9386

TT

199.8 ± 35.2

198.8 ± 37.7

214.6 ± 39.2

199.5 ± 36.8

0.0146

p value2

0.0595

0.3612

 < 0.0001

0.4070

 
  1. Data are expressed as means ± standard deviations.
  2. 1General linear models by CETP genotypes in each group, and differences between alcohol consumption and ALDH2 genotype.
  3. 2General linear models were used to assess CETP genotype differences in variables between alcohol consumption and total cholesterol by ALDH2 genotype.
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