Table 1 Eight instrumental SNPs and their association summary reported at the discovery stage15.

From: Mendelian randomization study of the effect of coronary artery calcification on atherosclerotic cardiovascular diseases

SNPs

Chr

Closest reference gene*

Beta coefficient

SE

P value (Discovery stage)

Allele frequency

Association with P < 5.00 × 10−8

rs1333049

9

(CDKN2B)

0.269

0.03

7.58 × 10−19

0.47

rs9349379

6

PHACTR1

0.211

0.032

2.65 × 10−11

0.59

Association with 5.00 × 10−8 < P < 5.00 × 10−6

rs2026458

6

PHACTR1

0.162

0.031

1.78 × 10−7

0.46

rs3809346

13

COL4A2

0.154

0.032

1.25 × 10−6

0.43

rs6783981

3

SERPINI1

0.14

0.03

3.94 × 10−6

0.51

rs17676451

12

HAL

0.17

0.037

4.08 × 10−6

0.22

rs6604023

1

(CDC7)

0.184

0.04

4.29 × 10−6

0.18

rs8001186

13

(IRS2)

0.148

0.032

4.51 × 10−6

0.67

  1. SNPs single-nucleotide polymorphisms; Chr chromosome; SE standard error; Sample size = 9961.
  2. *Genes for SNPs that are outside the transcript boundary of the protein-coding gene are shown in parentheses [e.g., (CDKN2B)].
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