Figure 6 | Scientific Reports

Figure 6

From: Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

Figure 6

Plasma concentration of S-warfarin and its hydroxy metabolites after the intravenous administration of S-warfarin (4.0 mg/kg) in non-humanized liver mice and humanized liver mice. The plasma concentrations of S-warfarin, 4′-hydroxywarfarin, 6-hydroxywarfarin, and 7-hydroxywarfarin in wild-type (circle) or POR cKO (triangle) mice with non-humanized or humanized livers were measured at 0.5, 1, 2, 4, 7, 24, 48, and 72 h after the intravenous administration of S-warfarin (4.0 mg/kg). Each group consists of two mice. The levels of 8- and 10-hydroxywarfarin were below the detection limit in all samples.

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