Table 1 Pharmacokinetic parameters for caffeine, warfarin, omeprazole, metoprolol, and midazolam in wild-type mice and POR cKO mice after single simultaneous oral administration (1.0 mg/kg each).

From: Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

Drug

Mouse

Cmax (ng/mL)

AUC0-inf (µg h/mL)

AUC ratioa

Caffeine

Wild-type mice

630 ± 160

2200 ± 250

–

POR cKO mice

2100 ± 400***

23,000 ± 7000***

10

Warfarin

Wild-type mice

2100 ± 300

29,000 ± 3000

–

POR cKO mice

4600 ± 1500***

150,000 ± 70,000***

5.2

Omeprazole

Wild-type mice

3.4 ± 1.3

6.6 ± 2.4

–

POR cKO mice

78 ± 61**

76 ± 59**

12

Metoprolol

Wild-type mice

3.5 ± 1.2

3.6 ± 0.5

–

POR cKO mice

130 ± 40***

190 ± 20***

53

Midazolam

Wild-type mice

4.7 ± 2.3

6.9 ± 2.6

–

POR cKO mice

110 ± 45***

810 ± 450***

117

  1. aRatios of AUC0-inf in POR cKO mice to that in wild-type mice. Cmax and AUC0-inf represent the mean ± SD of six animals (wild-type mice) and nine animals (POR cKO mice). **p < 0.01 and ***p < 0.001 vs. wild-type mice.
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