Table 2 Comparion clinical and lesion characteristics in vessels with DS > 50% between the anatomical–functional mismatch and non-mismatch groups.

From: Impact of overestimation of fractional flow reserve by adenosine on anatomical–functional mismatch

 

Mismatch

Pd/PaADN > 0.80

(n = 72)

Non-mismatch

Pd/PaADN ≤ 0.80

(n = 99)

p value

Age, yrs

72 (66–78)

72 (65–78)

0.466

Male, n (%)

55 (76%)

82 (83%)

0.298

Body mass index, kg/m2

23.6 (21.7–25.8)

23.8 (22.2–26.4)

0.278

Hypertension, n (%)

47 (65%)

65 (66%)

0.959

Diabetes mellitus, n (%)

29 (40%)

42 (42%)

0.553

Dyslipidemia, n (%)

58 (81%)

76 (76%)

0.779

Target vessel (LAD), n (%)

21 (29%)

72 (73%)

 < 0.001

Proximal lesion*, n (%)

19 (26%)

38 (38%)

0.100

Multivessel disease, n (%)

41 (57%)

53 (54%)

0.658

Quantitative coronary angiography

Reference diameter, mm

3.1 (2.6–3.5)

2.7 (2.2–3.2)

0.001

Minimal luminal diameter, mm

1.3 (1.1–1.5)

1.1 (0.9–1.3)

 < 0.001

DS, %

55.8 (52.8–61.3)

59.0 (53.9–64.9)

0.038

Lesion length, mm

11.2 (7.9–15.8)

13.2 (9.3–20.8)

0.029

Hemodynamic parameters

Heart rate at baseline, beats/min

67 (61–75)

68 (62–77)

0.749

Pa at baseline, mmHg

92 (82–106)

90 (82–102)

0.349

Pd/Pa ratio at baseline

0.97 (0.93–0.99)

0.88 (0.84–0.92)

 < 0.001

Pd/PaADN

0.86 (0.82–0.89)

0.72 (0.65–0.77)

N.A

Pd/PaPAP

0.84 (0.80–0.87)

0.69 (0.61–0.76)

N.A

  1. Values are expressed as medians (interquartile ranges) or frequencies (percentages).
  2. The mismatch was defined as DS > 50% and Pd/PaADN > 0.80, and the non-mismatch as DS > 50% and Pd/PaADN ≤ 0.80.
  3. *Proximal location was defined as Syntax segments 1, 5, 6, and 11.
  4. DS diameter stenosis, LAD left anterior descending coronary artery, Pa aortic pressure, Pd/Pa distal-to-aortic pressure ratio, Pd/PaADN distal-to-aortic pressure ratio associated with adenosine, Pd/PaADN distal-to-aortic pressure ratio associated with papaverine.
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