Figure 1 | Scientific Reports

Figure 1

From: Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men

Figure 1

Schematic representation of the designed human model. Blood samples were collected three times. The first collection was done before any pharmacological treatment and represents testosterone and gonadotropins at baseline levels. During the same visit, after blood collection, all subjects received a subcutaneous injection of gonadotropin-releasing hormone antagonist (GnRHa, 240 mg, Degarelix, Ferring Pharmaceuticals, Sweden). Three weeks later, subjects' blood samples were collected again, corresponding to low testosterone and gonadotropin levels. All participants then received an intramuscular injection of testosterone undecanoate (1000 mg, Nebido, Bayer Pharmaceuticals, Germany). After two weeks, the last blood samples were collected, corresponding to testosterone restored samples and low gonadotropin levels.

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