Table 2 Metabolites associated with testosterone level.

From: Plasma metabolome study reveals metabolic changes induced by pharmacological castration and testosterone supplementation in healthy young men

Class or Subclass

Compound

Log2 Fold change

Trend

B versus L1

L × R2

B × R3

Amino acids, peptides, and analogues

Arginine

0.78*

− 0.34

0.43

TR

Acetyl-L-methionine

0.83*

− 0.32

0.51

TR

Serine

0.8*

− 0.54*

0.26

R

Pyroglutamic acid

0.63*

− 0.46

0.17

TR

Creatinine

0.89*

− 0.48*

0.42

R

Leucine/Isoleucine

− 0.74*

0.66*

− 0.08

R

Citrulline

0.66*

− 0.46*

0.2

R

N(5)-Acetyl-L-ornithine

0.52*

− 0.19

0.32

TR

Glutamine

0.74*

− 0.27

0.46

TR

N-Acetylvaline

0.5*

− 0.51*

− 0.01

R

Myristoylglycine

− 1.56*

0.37

− 1.19*

TR

Ornithine

0.63*

− 0.55*

0.08

R

Carboxylic acids and derivatives

Succinic acid

0.88*

− 0.51

0.36

TR

Fatty Acyls

(2E)-hexadecenoylcarnitine

0.68*

− 0.6*

0.07

R

Palmitic Acid

− 1.19*

0.27

− 0.92*

TR

Meglutol

0.76*

− 0.44

0.32

TR

pentadecanoic acid

− 1.52*

0.31

− 1.21*

TR

cis-5,8,11,14,17-Eicosapentaenoic acid

− 0.83*

0.1

− 0.73*

TR

8Z,11Z,14Z-Eicosatrienoic acid

− 0.91*

0.04

− 0.88*

TR

3-[(15Z,19Z)-11,12-Dihydroxy-15,19-dotriacontadien-1-yl]-5-methyl-2(5H)-furanone

0.71*

− 0.31

0.4

TR

2,4-dihydroxyheptadec-16-ynyl acetate

− 1.56*

0.4

− 1.17*

TR

3-[(19Z)-15,16-Dihydroxy-19-dotriaconten-1-yl]-5-methyl-2(5H)-furanone

− 1.03*

0.52

− 0.51

TR

2-Hydroxy-3-(pentadecanoyloxy)propyl (6Z,9Z,12Z,15Z)-6,9,12,15-octadecatetraenoate

0.64*

− 0.05

0.59*

TR

Glycerophospholipids

(2R)-1-[(6Z,9Z,12Z,15Z)-6,9,12,15-Octadecatetraenoyloxy]-3-(phosphonooxy)-2-propanyl (15Z)-15-tetracosenoate

1.35*

− 0.17

1.18*

TR

1-Oleoyl-2-Stearoyl-sn-Glycero-3-Phosphocholine

0.94*

− 0.09

0.85*

TR

1-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine

0.83*

− 0.61*

0.22

R

(2R)-2-Acetoxy-3-[(9Z)-9-octadecen-1-yloxy]propyl 2-(trimethylammonio)ethyl phosphate

0.67*

− 0.45

0.22

TR

(18R)-24-Amino-21-hydroxy-21-oxido-15-oxo-16,20,22-trioxa-21lambda ~ 5 ~ -phosphatetracosan-18-yl (6Z,9Z,12Z)-6,9,12-octadecatrienoate

− 0.57*

0.57*

0.004

R

1-hexadecanoyl-sn-glycero-3-phosphoethanolamine

1.05*

− 0.45

0.59*

TR

Hydroxy acids and derivatives

3-Hydroxy-cis-5-tetradecenoylcarnitine

0.62*

− 0.47

0.15

TR

12-Hydroxydodecanoic acid

1.49*

− 0.18

1.31*

TR

Imidazopyrimidines

Uric acid

0.98*

− 0.66*

0.32

R

Keto acids and derivatives

Acetonedicarboxylic Acid

0.88*

− 0.38

0.5

TR

Non-metal oxoanionic compounds

Phosphoric acid

− 1.68*

0.44*

− 1.25*

R

Organic phosphoric acids and derivatives

Dimethylphosphate

− 1.69*

0.48*

− 1.2*

R

Organonitrogen compounds

Anandamide

1.04*

− 0.1

0.94*

TR

Carbohydrates and carbohydrate conjugates

beta-D-Mannopyranose

1.1*

− 0.12

0.98*

TR

(2xi)-D-gluco-heptonic acid

0.8*

− 0.01

0.79*

TR

2,3-Diketogulonic Acid

1.05*

− 0.51*

0.54*

R

(2R)-DIMBOA glucoside

− 1.36*

0.61*

− 0.75*

R

Phenols

p-Cresol

− 1.55*

0.51*

− 1.04*

R

Prenol lipids

7-Isopropyl-4a-methyl-1-methylene-1,2,3,4,4a,9,10,10a-octahydrophenanthrene

1.3*

− 0.62*

0.69*

R

5-Isopropyl-2-methyl-2-cyclohexen-1-one

1.02*

− 0.37

0.65*

TR

Coenzyme Q2

0.75*

− 0.4

0.34

TR

(3R,6'R)-3',4',5',18'-Tetradehydro-5',6'-dihydro-beta,beta-caroten-3-ol

0.95*

− 0.12

0.83*

TR

Sphingolipids

Ceramide (d18:1/24:0)

0.67*

− 0.06

0.61*

TR

  1. Do not include putative metabolites present in Table 1. R = Recovery profile (p-value < 0.05, Low vs. Restored)/TR = Tendency to recovery (p value > 0.05, Low vs. Restored))/ NR = Non-restored. 2B versus L = Basal versus Low (Basal–Low) / 3L versus R = Low versus Restored (Low-Retored)/ 4B versus R = Basal versus Restored (Basal – Restored) / *p value < 0.05, Pairwise comparison (Turkey Posthoc). Log2Fold Change: negative values were linked to relatively high abundant metabolites and positive values to relatively low abundant metabolites.
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