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Figure 1

From: Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice

Figure 1

Combination treatment of VT and ampicillin reduced pulmonary permeability 30 h p.i. Vasculotide (VT) (500 ng/100 µl intravenously (i.v.)) or phosphate buffered saline (PBS), and ampicillin (0.4 mg/kg bw intraperitoneally (i.p.)) or 0.9% saline were administered 22 h after Streptococcus pneumonia (S. pn.) infection (control: PBS + hyaluronidase). The 6-h ventilation phase began 24 h post infection (p.i). A second dose of VT together with 1 mg human serum albumin (HSA) was administered 1.5 h prior to termination of the experiment. Cell-free bronchoalveolar lavage fluid (BALF)/plasma ratio for HSA was calculated as a measure of permeability. Values are listed as median + IQR with minimum and maximum values, individual values are shown as dots (control n = 4, all other groups n = 7–9; *p < 0.05, Mann–Whitney-U-Test).

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