Table 1 Comparison between different biosensors reported for CEA and CYFRA 21-1 detection and the ones developed in this research.
From: Simple diagnosis of cancer by detecting CEA and CYFRA 21-1 in saliva using electronic sensors
Sl. no. | Type of sensor | Sensing material | Target Bio marker | Lowest measured concentration | References |
|---|---|---|---|---|---|
1 | ELISA | – | CEA, CYFRA-21 | ~ng/mL | |
2 | Electrochemical immunosensor | Cubic CeO2 implanted reduced graphene oxide based biosensor | CYFRA 21-1 | 0.625 pg /mL | |
3 | Electrochemical immunosensor | Polyhydroquinone-graphene composite | CYFRA-21 | 2.3 pg/mL | |
4 | Electrochemical immunosensor | Amine-functionalized MoO3@RGO Nanohybrid-Based Biosensor | CEA | 0.001 ng/mL | |
5 | Electrochemical immunosensor | A sandwich-type electrochemical immunosensor using polythionine/AuNPs nanocomposites | CEA | 0.3 ng/mL | |
6 | This work | RGO/MEL/antibody/BSA/antigen | CEA, CYFRA-21 | 1 pg/mLfor both the antigens |
