Table 1 EC₅₀ values for CREB3L1-deficient HCC1806 cells, as compared to HCC1806 + HA-CREB3L1 cells.

From: Homoharringtonine demonstrates a cytotoxic effect against triple-negative breast cancer cell lines and acts synergistically with paclitaxel

Drug name	Drug target or class of agent	HCC1806 (EC₅₀, nM)^a	HCC1806 + HA-CREB3L1 (EC₅₀, nM)^a	EC₅₀ range	p-value^b	Comments
Homoharringtonine	Inhibits protein translation	29 ± 4	42 ± 7	Med nM	3.919E−04	CREB3L1-Dependent
Cladribine	Nucleoside Analog	92 ± 44	182 ± 60	Med nM	0.002	CREB3L1-Dependent
Lanatoside C	Na+/K+ ATPase	143 ± 85	233 ± 100	Med nM	0.056	CREB3L1-Dependent
Palbociclib Isethionate	CDK4/6	500 ± 130	1300 ± 490	High nM	1.882E−04	CREB3L1-Dependent
Sanguinarine Cl	STAT3, MMPs	540 ± 120	800 ± 200	High nM	0.249	CREB3L1-Independent
Zinc Pyrithione	Anti-bacterial, Anti-fungal	157 ± 62	266 ± 52	Med nM	0.319	Nearly CREB3L1-dependent
Hydroxy Camptothecin	Topoisomerase I	1.5 ± 0.2	1.3 ± 0.2	Low nM	0.130	CREB3L1-Independent
Irinotecan	Topoisomerase I	211 ± 43	116 ± 24	Med nM	0.028	CREB3L1 more sensitive
Teniposide	Topoisomerase II	74 ± 30	73 ± 13	Med nM	0.968	CREB3L1-Independent
Cephalomannine	Microtubules	3.8 ± 0.7	4.7 ± 1.6	Low nM	0.119	CREB3L1-Independent
Nocodazole	Tubulin and microtubules	27 ± 6	12 ± 1	Low nM	0.011	CREB3L1 more sensitive
Doxorubicin	Anthracycline	13 ± 4	17 ± 6	Low nM	0.244	CREB3L1-Independent
Doxorubicin HCl	Anthracycline	36 ± 11	51 ± 5	Med nM	0.102	CREB3L1-Independent
Daunorubicin HCl	Anthracycline	34 ± 6	32 ± 2	Med nM	0.591	CREB3L1-Independent
Cyclocytidine HCl	Nucleotide Analog	32 ± 8	40 ± 5	Med nM	0.241	CREB3L1-Independent
Carfilzomib	Proteasome	8.3 ± 0.5	7.7 ± 0.5	Low nM	0.235	CREB3L1-Independent
Bortezomib	20S proteasome	12 ± 6	7.9 ± 3.6	Low nM	0.125	CREB3L1-Independent
MLN9708	20S proteasome	85 ± 12	91 ± 16	Med nM	0.530	CREB3L1-Independent
MLN2238	20S proteasome	251 ± 22	233 ± 9	Med nM	0.277	CREB3L1-Independent
Digitoxin	Na+/K+ ATPase	49 ± 11	48.8 ± 0.7	Med nM	0.989	CREB3L1-Independent
Ouabain Octahydrate	Na+/K+ ATPase	62 ± 8	54 ± 10	Med nM	0.344	CREB3L1-Independent
Digoxin	Na +/K+ ATPase	95 ± 31	113 ± 35	Med nM	0.531	CREB3L1-Independent
Panobinostat	HDACs	15 ± 5	12 ± 3	Low nM	0.009	CREB3L1 more sensitive
Romidepsin	HDACs	0.87 ± 0.07	0.92 ± 0.06	Low nM	0.370	CREB3L1-Independent
Belinostat	HDACs	131 ± 15	207 ± 85	Med nM	0.457	CREB3L1-Independent
Octenidine	Anti-infective	530 ± 70	630 ± 220	High nM	0.487	CREB3L1-Independent
Cobimetinib	MEK1 pathway	3400 ± 500	3100 ± 300	High nM	0.184	CREB3L1-Independent

Drugs with CREB3L1-dependent effects are in bold.
^aMean ± SD from at least 3 replicate measurements.
^bp-value; student t-test for significance, HCC1806 + HA-CREB3L1 as compared to HCC1806.

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Table 1 EC₅₀ values for CREB3L1-deficient HCC1806 cells, as compared to HCC1806 + HA-CREB3L1 cells.

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