Table 1 Characteristics of O-ZSF1 and L-ZSF1 rats at 20 and 32 weeks of age.

From: Tubulin expression and modification in heart failure with preserved ejection fraction (HFpEF)

 

20 weeks

32 weeks

O-ZSF1

L-ZSF1

p-value

O-ZSF1

L-ZSF1

p-value

Body weight [g]

468 ± 28

235 ± 9

 < 0.001

529.2 ± 23.1

283.4 ± 8.8

 < 0.001

Heart weight [g]

1.38 ± 0.07

0.93 ± 0.05

 < 0.001

1.56 ± 0.15

1.16 ± 0.12

0.002

Heart rate [bpm]

214 ± 17

216 ± 18

0.812

222 ± 9

220 ± 22

0.839

E/e′

21.7 ± 3.6

15.0 ± 2.8

 < 0.001

22.4 ± 2.5

17.8 ± 4.9

0.158

LVEF [%]

63 ± 15

55 ± 12

0.140

53.1 ± 5.9

58 ± 6.3

0.219

LVEDV [cm3]

0.60 ± 0.11

0.46 ± 0.04

 < 0.001

0.97 ± 0.16

0.6 ± 0.062

0.002

LVDd [cm]

0.94 ± 0.11

0.79 ± 0.06

 < 0.001

0.75 ± 0.05

0.66 ± 0.04

0.006

NT-proBNP [pg/ml]*

1200 ± 338

895 ± 371

0.047

266 ± 64

340 ± 49

0.051

  1. Mean and standard deviation are shown; p-value was calculated using Student’s t-test. Bpm (beats per minute), E/e′ (ratio of mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (e′)), LVEF (left ventricular ejection fraction), LVEDV (left ventricular end-diastolic volume), LVDd (left ventricular diastolic diameter), NT-proBNP (N terminal B natriuretic peptide).
  2. *Due to different manufacturers, the results at 20 and 32 weeks are not directly comparable.
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