Figure 3
From: Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice
Nr4a1 downstream target, Cartpt, is regionally activated after 10 days of investigator-administered cocaine in male mice. (A) There was no change in mRNA levels of Cartpt, Drd1, Drd2, or A2a in the male mouse STR following 10 days of investigator-administered cocaine (n = 5–6/group). There was no change in (B) H3K4me3 (n = 6/group) or (C) H3K27me3 (n = 6/group) at Cartpt in the male mouse STR after 10 days of investigator-administered cocaine. (D) There was no change in mRNA levels of Cartpt, Drd1, Drd2, or A2a in the male mouse HPC following 10 days of investigator-administered cocaine (n = 7–8/group). There was no change in (E) H3K4me3 (n = 7/group) or (F) H3K27me3 (n = 6–8/group) at Cartpt in the male mouse HPC after 10 days of investigator-administered cocaine. (G) There was an increase in mRNA levels of Cartpt, a trending decrease in mRNA levels of Drd1 and Drd2, and no change in mRNA levels of A2a in the male mouse PFC following 10 days of investigator-administered cocaine (n = 5–6/group). There was no change in (H) H3K4me3 (n = 8/group) or (I) H3K27me3 at Cartpt in the male mouse PFC after 10 days of investigator-administered cocaine (n = 5–6/group). *p < 0.05. #p < 0.10. Data are shown as mean ± SEM. STR, striatum; HPC, hippocampus; PFC, prefrontal cortex.
