Figure 6 | Scientific Reports

Figure 6

From: DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity

Figure 6

Mushroom body neuron overexpression of human Tau, tAβ42 and mnb cause memory deficits improved by DYRK1A inhibitors. (A) Overexpression of human tau, tAβ42 and mnb throughout the fly memory centre, the mushroom body (OK107-Gal4) decreased 1 h memory (performance index (PI)) compared to OK107/ + control. DYR219 increased the memory performance of human Tau overexpressing flies and was able to completely rescue the memory loss of both human Tau and mnb overexpressors. DYR533 significantly increased the memory of human tAβ42 flies to a level indistinguishable than control. Data was analysed with 2-way ANOVA with Dunnett's post hoc multiple comparisons test, * and # as listed in the Methods statistics section and previous legends. Mean PI was taken from four independent experiments. Neither mushroom body overexpression of mnb, human tAβ42 and human Tau or DYR219 or DYR533 treatment change the response of the fly to (B) octanol, (C) MCH or (D) shock compared to control. Average % avoidance was taken from 3–4 independent experiments with each n = 30–50 flies per experiment per genotype.

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