Figure 2

The boxplot (median and IQR) for the plasma miR-186 levels with TMX-resistant patients having respiratory symptoms and for the serum HIF-1α levels with TMX-resistant patients having metastases. In this figure, Mann–Whitney test was used to compare two independent groups with quantitative data and non-parametric distribution. This box plot figure shows a significant negative association between miR-186 and respiratory symptoms at test value of − 2.376 and P value of 0.018. It also shows a significant positive association between HIF-1 α and metastases at test value of − 2.224 and P value of 0.026. Logistic regression analysis showed that there was statistically significant association found between miR-186 ≤ 376.08 and respiratory symptoms with P value = 0.005 and OR (95% CI) of 8.667 (1.904–39.442), where respiratory symptoms rate increase as miR-186 decreases in TMX resistant patients. It also showed that there was statistically significant association found between HIF-1α > 1.12 and metastases with P value = 0.009 and OR (95% CI) of 6.171 (1.583–24.054), where metastases rate increase as HIF-1α increases in TMX resistant patients.