Table 3 Effect of DZN 20 mg/kg and CH 50 mg/kg, and DZN plus CH (12.5, 25, and 50 mg/kg) on DTH responses in BALB/c mice.

From: Potential protective effects of chrysin against immunotoxicity induced by diazinon

Groups

DTH 24 h

DTH 48 h

Control

26.37 ± 0.13

13.33 ± 1.99

DZN

14.54 ± 0.05 ***

8.83 ± 0.7

DZN + CH1

16.25 ± 0.01 +  +  + 

9.66 ± 2.45

DZN + CH2

18.64 ± 0.16 +  +  + 

9.67 ± 1.72

DZN + CH3

19.42 ± 0.19 +  + 

17.50 ± 2.21 + 

CH3

23.01 ± 0.03 ***

18.83 ± 1.19

CTX 20 mg/kg

12.62 ± 0.06 ***

5.33 ± 0.55 *

  1. Data showed as mean ± SD, (*) shows the significant changes compared to controls, ( +) comparison with the diazinon-treated group. p < 0.05 and (***) or (+ +  + +) p < 0.001. DZN significantly reduced the DTH in sensitised animals compared to the control group after 24 h. CH at doses of 12.5, 25, and 50 mg/kg strongly neutralised the effect of DZN after 24 h. However, CH only at the highest dose of 50 mg/kg was able to neutralise the impact of DZN after 48 h on DTH responses in animals receiving DZN plus CH.
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