Table 5 The results of DZN 20 mg/kg and CH 50 mg/kg, CH and DZN plus CH (12.5, 25, and 50 mg/kg) on CH50 and specific Ab production in BALB/c mice.

From: Potential protective effects of chrysin against immunotoxicity induced by diazinon

Groups

CH50 (u/µL)

Anti-SRBC, HA titre (log 2)

Control

45.67 ± 2.14

7.6 ± 0.24

DZN

43.5 ± 1.87

6.2 ± 0.73 **

DZN + CH1

46.33 ± 2.53

7 ± 031

DZN + CH2

50 ± 2.30

7.2 ± 0.37 + 

DZN + CH3

48 ± 2.26

7.8 ± 0.2 +  + 

CH3

49 ± 1.88

7.8 ± 0.37

Dexamethasone 4 mg/kg

 

6.2 ± 0.73 **

  1. Data showed as mean ± SD, (*) shows the significant changes compared to controls, ( +) comparison with the diazinon-treated group. p < 0.05 and (***) or (+ +  + +) p < 0.001. The results of the HA test showed that producing specific anti-SRBC for evaluation of humoral immunity inhibited when animals received DZN. However, CH at the highest concentration, 50 mg/kg, was able to neutralise the inhibitory effect of DZN strongly. Albite and CH at doses of 12.5 and 25 mg/kg also statistically ameliorated the toxic effects of DZN plus CH. As an immune-inhibitory drug, dexamethasone also dramatically suppressed the specific antibody production compared to the control group. Moreover, complement hemolytic activity decreased in the DZN-receiving animal, but the result was not statistically significant.
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