Table 2 Signs and symptoms according to clinical outcome in individuals with SARS-CoV-2 infection and negative controls (n = 48).

From: Serum biomarkers associated with SARS-CoV-2 severity

Variables

Controls-C N = 9

Asymptomatic-A N = 14

Mild cases-M N = 13

Severe cases-S N = 12

p-value

Fever

Yes

0 (0.0%)

0 (0.0%)

8 (61.5%)

7 (58.3%)

 < 0.001a

Median (IQR)*

0 (0–0)

0 (0–0)

3 (0–4.0)

3.5 (0–5.5)

 < 0.001b

Cough

Yes

0 (0.0%)

0 (0.0%)

7 (53.8%)

9 (75.0%)

 < 0.001a

Median (IQR)*

0 (0–0)

0 (0–0)

3 (0–6.0)

3.5 (2.25–5.0)

 < 0.001b

Sore throat

Yes

0 (0.0%)

0 (0.0%)

2 (15.4%)

5 (41.7%)

0.009a

Median (IQR)*

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–5.0)

0.014b

Nasal congestion

Yes

0 (0.0%)

0 (0.0%)

9 (69.2%)

7 (58.3%)

 < 0.001a

Median (IQR)*

0 (0–0)

0 (0–0)

4 (0–7.0)

3.5 (0–5.0)

 < 0.001b

Dyspnea

Yes

0 (0.0%)

0 (0.0%)

1 (7.7%)

9 (75.0%)

 < 0.001a

Median (IQR)*

0 (0–0)

0 (0–0)

0 (0–0)

4 (1.5–5.25)

 < 0.001b

Chest pain

Yes

0 (0.0%)

0 (0.0%)

1 (7.7%)

1 (8.3%)

0.690a

Median (IQR)*

0 (0–0)

0 (0–0)

0 (0–0)

0 (1.5–5.25)

0.598b

Headache

Yes

0 (0.0%)

0 (0.0%)

9 (69.2%)

4 (33.3%)

 < 0.001a

Median (IQR)*

0 (0–0)

0 (0–0)

4 (0–7.0)

0 (0–1.75)

 < 0.001b

Loss of smell

Yes

0 (0.0%)

0 (0.0%)

8 (61.5%)

3 (25.0%)

 < 0.001a

Median (IQR)*

0 (0–0)

0 (0–0)

2 (0–3.0)

0 (0–0.25)

0.003b

Loss of taste

Yes

0 (0.0%)

0 (0.0%)

8 (61.5%)

3 (25.0%)

 < 0.001a

Median (IQR)*

0 (0–0)

0 (0–0)

2 (0–4.0)

0 (0–0.25)

0.003b

  1. Mild Cases-M Non-hospitalized; Severe Cases-S Hospitalized.
  2. a Fisher’s exact test.
  3. b Kruskal–Wallis test.
  4. *Median of days between symptom onset and recruitment date (IQR, interquartile range).