Figure 4

Bubble plot of enriched pathways from the miRNA-gene targets. (A) Pathways for gene targets that were expressed in human brain tissue of lead exposure associated miRNAs. The pathways marked with a star were potentially AD-related based on literature (Supplementary Table S1). The group lead related refers to all gene targets (associated with lead-affected miRNAs’ expression) enriched pathways, lead inversely related refers to inversely genes (positively related to miRNAs that were negatively related to lead exposure or negatively related to miRNAs that were positively related to lead exposure) enriched pathways, lead positively related refers to positively genes (positively related to miRNAs that were positively related to lead exposure or negatively related to miRNAs that were negatively related to lead exposure) enriched pathways, and cluster AD vs nonAD refers to pathways of 27 genes that were obtained via feature selection as described in Fig. 5; (B) Pathways for each miRNA’s gene targets that were associated with miRNA expression and expressed in human brain tissue. The pathways marked with star were potentially AD relevant according to literature (Supplementary Table S1). The targets of miR-3651 and miR-627 were not significantly enriched in any KEGG pathways.