Figure 6

The co-regulation of the complex interaction of miRNAs, TFs and gene targets based on data integration from different data sources. This figure was made using Cytoscape. For the four miRNAs, they were linked to their targets in this network based on coefficients of linear mixed model (Supplementary Table S3), some targets are TFs. In addition, the TFs-miRNAs regulations from TransmiR v2 database⁵⁷ and TFs-targets regulations from TRRUST v2 database⁵⁸ were also visualized based on evidence level (Supplementary Table S5). In total, there are 13 TFs became hubs of the network including ZBTB7A, MYB, NR2F2, FOS, NFYA, STAT1, SP2, CREB1, ETV3, EZHZ, EP300, TP53 and NOTCH1. Detailed interact information was described in Supplementary Tables S3 and S5.