Table 3 Subgroup analysis of the association of SUA with the risk of CRC.

From: The relationship between serum uric acid and colorectal cancer: a prospective cohort study

 

T1 group

T2 group

T3 group

Case/person-years

Adjusted HRs (95% CI)

Case/person-years

Adjusted HRs (95% CI)

Case/person-years

Adjusted HRs (95% CI)

Sex

Womena

22/78,877

Ref

30/79,804

1.07 (0.62, 1.87)

32/76,883

1.25 (0.72, 2.17)

Menb

142/306,682

Ref

158/303,602

1.11 (0.90, 1.38)

199/296,223

1.58 (1.10, 2.51)

p for interaction

   

0.962

  

Age (years)

Age ≤ 45

17/133,763

Ref

19/118,813

1.82 (0.96, 3.44)

21/108,964

2.00 (1.10, 3.64)

45 < Age ≤ 65

114/218,372

Ref

119/223,301

1.55 (0.87, 2.99)

147/201,233

1.76 (1.22, 2.14)

Age > 65

33/33,424

Ref

50/41,294

1.68 (0.64, 4.42)

63/62,909

1.70 (0.68, 4.26)

p for interaction

   

0.338

  

BMI (kg/m2)

BMI < 24

83/228,576

Ref

82/188,049

1.82 (0.96, 3.44)

83/132,987

1.98 (1.08, 3.60)

24 ≤ BMI < 28

63/125,979

Ref

70/137,704

1.20 (0.66, 2.20)

87/157,283

1.21 (0.69, 2.13)

BMI ≥ 28

18/31,004

Ref

36/57,653

1.68 (0.64, 4.42)

61/82,836

1.78 (0.73, 4.29)

p for interaction

   

0.951

  
  1. All models were adjusted for age, sex, BMI, TG, TC, CRP, TBIL, ALT, diabetes, hypertension, family income, educational background, marital status, salt consumption, current smoker, drinking status, physical activity, chronic kidney disease, and family history of cancer except the stratified factors.
  2. aThe cut-offs of the SUA among females were 211.00 and 267.00 μmol/L, respectively.
  3. bThe cut-offs of the SUA among males were 262.00 and 329.00 μmol/L, respectively.
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