Table 3 Metabolic pathways influenced by significative metabolites in hyperketonemic ewes (Group HYK; n = 18; BHB ≥ 0.80 mmol/L) with their p-value.

From: Evaluation of the metabolomic profile through 1H-NMR spectroscopy in ewes affected by postpartum hyperketonemia

Metabolic pathways

Total1

Hits2

Metabolites3

p-value

Holm-Bonferroni corrected

Aminoacyl-tRNA biosynthesis

48

5

Asparagine, glutamine, alanine, threonine and tyrosine

 < 0.0001

0.003

Alanine, aspartate and glutamate metabolism

28

4

Asparagine, alanine, glutamine and succinate

 < 0.0001

0.007

d-Glutamine and d-glutamate metabolism

6

1

Glutamine

0.001

0.095

Glycolysis/gluconeogenesis

26

2

Ethanol and acetate

0.023

1.0

Glyoxylate and dicarboxylate metabolism

32

2

Acetate and glutamine

0.033

1.0

Phenylalanine, tyrosine and tryptophan biosynthesis

4

1

Tyrosine

0.036

1.0

  1. 1Total number of metabolites in the pathway based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database.
  2. 2Number of metabolites influenced the pathways in this experiment.
  3. 3Metabolites identify by KEGG database.
Back to article page