Table 3 The modulatory effects of O. vulgare on serum cellular toxicity markers, and ammonia in the HE rat model.

From: Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy

Groups

Parameters

Control

O. vulgare

100

O. vulgare 200

ATT + vehicle

O. vulgare 100 + ATT

O. vulgare 200 + ATT

SILY 100 + ATT

AST(IU/L)

101.60 ± 2.15

100.30 ± 3.36

100.60 ± 3.42

205.4 ± 3.84 ***

157.40 ± 3.92 ***†††$$$

123.00 ± 6.75 *†††

121.30 ± 5.16 *†††

ALT (IU/L)

31.43 ± 2.85

31.43 ± 2.32

31.14 ± 2.20

116.00 ± 3.37 ***

69.57 ± 2.53 ***†††$$$

45.86 ± 4.07 *†††

46.00 ± 2.70 *†††

Total bilirubin (mg/dL)

0.67 ± 0.02

0.66 ± 0.01

0.64 ± 0.02

1.87 ± 0.02 ***

0.82 ± 0.04 **†††

0.79 ± 0.03 *†††

0.78 ± 0.03 *†††

Total protein (g/dL)

7.18 ± 0.16

7.32 ± 0.13

7.38 ± 0.16

4.72 ± 0.29 ***

5.85 ± 0.26 **†

6.14 ± 0.25 *†††

6.07 ± 0.21 *††

Total cholesterol (mg/dL)

97.33 ± 1.84

96.20 ± 1.54

95.76 ± 1.55

202.10 ± 1.98 ***

141.00 ± 4.08 ***†††$$$

110.10 ± 2.75 *†††

109.80 ± 2.28 *†††

Ammonia (μmol/L)

36.29 ± 3.13

35.86 ± 2.37

39.14 ± 2.55

123.30 ± 3.23 ***

90.00 ± 2.18 ***†††$$$

50.00 ± 3.06 *†††

51.57 ± 4.13 *†††

  1. Values are means ± SEM. ALT: alanine aminotransferase, AST: aspartate aminotransferase, O. vulgare: Origanum vulgare, SLY: silymarin. *p < 0.05; **p < 0.01; ***p < 0.001 (vs. the negative control group); †p < 0.01; ††p < 0.01; †††p < 0.001 (vs. the HE positive control group, which received vehicle). $$$ p < 0.001 (vs. the HE group, which received silymarin).
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