Table 4 Comparison of the rate of thinning of retinal nerve fiber layer thickness and Bruch’s membrane opening minimum rim width of subjects with open-angle glaucoma grouped by mean deviation.

From: Comparison of retinal nerve fiber layer thickness and Bruch’s membrane opening minimum rim width thinning rate in open-angle glaucoma

Variables	MD > − 2 dB (H)	− 2 dB ≥ MD > − 6 dB (M)	− 6 dB ≥ MD > − 12 dB (L)	P-value
Rate of RNFLT thinning^† (µm/y)
Rate of global RNFLT thinning	− 0.94 (p < 0.001)	− 1.26 (p < 0.001)	− 1.71 (p = 0.005)	0.192^‡	0.073^§	0.458^¶
Rate of superotemporal RNFLT thinning	− 1.61 (p = 0.021)	− 1.91 (p < 0.001)	− 1.63 (p < 0.001)	0.338^‡	0.412^§	0.507^¶
Rate of temporal RNFLT thinning	− 0.77 (p = 0.003)	− 1.11 (p < 0.001)	− 0.87 (p = 0.001)	0.329^‡	0.788^§	0.279^¶
Rate of inferotemporal RNFLT thinning	− 2.66 (p = 0.022)*	− 1.99 (p < 0.001)*	− 2.14 (p < 0.001)*	0.511^‡	0.864^§	0.806^¶
Rate of inferonasal RNFLT thinning	− 1.00 (p = 0.040)	− 1.00 (p < 0.001)	− 1.90 (p = 0.004)	0.982^‡	0.094^§	0.130^¶
Rate of nasal RNFLT thinning	− 0.43 (p = 0.014)	− 0.85 (p < 0.001)	− 1.39 (p = 0.033)	0.012^‡	0.040^§	0.138^¶
Rate of superonasal RNFLT thinning	− 0.25 (p = 0.693)	− 1.62 (p < 0.001)	− 1.65 (p < 0.001)	0.119^‡	0.077^§	0.910^¶
Rate of BMO-MRW thinning^† (µm/y)
Rate of global BMO-MRW thinning	− 1.62 (p < 0.001)	− 3.24 (p < 0.001)	− 2.94 (p < 0.001)	0.003^‡	0.073^§	0.706^¶
Rate of superotemporal BMO-MRW thinning	− 2.42 (p < 0.001)	− 4.30 (p < 0.001)*	− 5.39 (p < 0.001)*	0.027^‡	0.006^§	0.284^¶
Rate of temporal BMO-MRW thinning	− 1.67 (p < 0.001)	− 2.48 (p < 0.001)	− 3.31 (p < 0.001)	0.208^‡	0.013^§	0.330^¶
Rate of inferotemporal BMO-MRW thinning	− 2.95 (p < 0.001)*	− 4.17 (p < 0.001)	− 3.17 (p = 0.001)	0.155^‡	0.894^§	0.184^¶
Rate of inferonasal BMO-MRW thinning	− 2.56 (p < 0.001)	− 3.00 (p < 0.001)	− 2.33 (p = 0.005)	0.517^‡	0.746^§	0.354^¶
Rate of nasal BMO-MRW thinning	− 1.19 (p = 0.024)	− 2.69 (p < 0.001)	− 2.49 (p = 0.002)	0.040^‡	0.156^§	0.763^¶
Rate of superonasal BMO-MRW thinning	− 1.67 (p = 0.047)	− 3.86 (p < 0.001)	− 2.07 (p = 0.065)	0.045^‡	0.799^§	0.144^¶

MD, mean deviation; RNFLT, retinal nerve fiber layer thickness; BMO-MRW, Bruch’s membrane opening minimum rim width.
*The highest value among the global and six Garway-Heath sectors.
^†Linear mixed model.
^‡Linear mixed model, mean deviation > − 2 dB versus − 2 dB ≥ mean deviation > − 6 dB (M).
^§Linear mixed model, mean deviation > − 2 dB versus − 6 dB ≥ mean deviation > − 12 dB.
^¶Linear mixed model, − 2 dB ≥ mean deviation > − 6 dB (M) versus − 6 dB ≥ mean deviation > − 12 dB.

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Table 4 Comparison of the rate of thinning of retinal nerve fiber layer thickness and Bruch’s membrane opening minimum rim width of subjects with open-angle glaucoma grouped by mean deviation.

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