Table 2 Risk factors associated with high tacrolimus intra-patient variability.
Univariable | Multivariable | |||
|---|---|---|---|---|
OR (95% CI) | P | OR (95% CI) | P | |
Age, per year | 0.997 (0.978–1.017) | 0.800 | ||
Female sex | 1.325 (0.912–1.926) | 0.140 | 1.102 (0.722–1.684) | 0.652 |
Body mass index, kg/m2 | 0.984 (0.932–1.038) | 0.554 | ||
MELD Na score, per point | 0.997 (0.976–1.018) | 0.759 | ||
Alcoholic liver disease | 1.237 (0.818–1.872) | 0.314 | ||
Hepatocellular carcinoma | 0.951 (0.678–1.333) | 0.770 | ||
Mean tacrolimus concentration, ng/mL | 0.820 (0.746–0.900) | < 0.001 | 0.825 (0.744–0.915) | < 0.001 |
Hematocrit, % | 0.977 (0.948–1.008) | 0.145 | 1.046 (1.003–1.091) | 0.037 |
Albumin, mg/dL, | 0.496 (0.346–0.711) | < 0.001 | 0.344 (0.212–0.556) | < 0.001 |
Total bilirubin, mg/dL | 0.944 (0.793–1.124) | 0.518 | ||
Cholesterol, mg/dL | 1.002 (0.999–1.006) | 0.173 | 1.002 (0.998–1.006) | 0.274 |
Creatinine, mg/dL | 0.968 (0.694–1.350) | 0.848 | ||
