Table 2 Analysis of the treatment effects on the logarithmic scale.

From: Dichloroacetate as a metabolic modulator of heart mitochondrial proteome under conditions of reduced oxygen utilization

Protein

AVE LOG FC DM/Control

ANTILOG AVE FC DM/Control

p value

2-way RM ANOVA

AVE LOG FC DM/ DM + DCA

ANTILOG AVE FC DM/ DM + DCA

p value

2-way RM ANOVA

Treatment*(diabetes)

Run*

Interaction*

Treatment*(DCA)

Run*

Interaction*

Identified proteins involved in the structure and regulation of mPTPs

ADT1

0.0571

1.0404

0.4834

0.4132

0.8809

0.6157

− 0.0022

0.9985

0.9641

0.9653

0.4191

0.9334

ADT2

0.1459

1.1064

0.1353

0.0773

0.7214

0.6299

0.1479

1.1080

0.1237

0.0758

0.9761

0.8784

AT5F1

0.1996

1.1484

0.2207

0.1870

0.8378

0.2739

0.0196

1.0137

0.9600

0.9542

0.3937

0.4676

ATP5H

0.1364

1.0992

0.2438

0.1741

0.4837

0.7052

− 0.1723

0.8874

0.1931

0.1275

0.8561

0.8974

ATP5I

0.0400

1.0281

0.7869

0.8261

0.1402

0.4508

0.1579

1.1157

0.2207

0.2516

0.7896

0.1343

ATP5L

0.2165

1.1619

0.2060

0.3588

0.1777

0.5036

− 0.0626

0.9576

0.4468

0.5173

0.2754

0.2720

ATPA

0.1824

1.1348

0.0231

0.0200

0.2807

0.9945

0.2385

1.1798

0.0131

0.0055

0.8264

0.2040

ATPB

− 0.0122

0.9916

0.8403

0.8057

0.2955

0.4380

− 0.0750

0.9493

0.2217

0.2836

0.1508

0.9389

ATPD

0.0000

1.0000

1.0000

   

0.0000

1.0000

1.0000

   

ATPG

0.1252

1.0907

0.2374

0.2396

0.9023

0.8206

0.1592

1.1167

0.1238

0.1597

0.9659

0.7465

ATPK

0.3882

1.3088

0.0339

0.0236

0.4148

0.2834

0.2173

1.1626

0.3029

0.2359

0.4021

0.4927

ATPO

0.2763

1.2111

0.0312

0.0119

0.2251

0.4210

0.1891

1.1400

0.0969

0.0884

0.0840

0.9947

KCRS

0.0968

1.0694

0.4411

0.3763

0.8954

0.6606

0.3311

1.2580

0.0286

0.0130

0.5674

0.3798

MPCP

0.1335

1.0970

0.3109

0.2290

0.9365

0.2746

− 0.0166

0.9885

0.7348

0.7185

0.6215

0.0870

VDAC1

0.2562

1.1943

0.0329

0.0172

0.9359

0.3094

0.2034

1.1514

0.0225

0.0400

0.1454

0.6139

VDAC2

0.0307

1.0215

0.5172

0.6774

0.5226

0.9976

0.1749

1.1289

0.1884

0.1453

0.8898

0.7527

VDAC3

− 0.1114

0.9257

0.5286

0.4746

0.6969

0.2010

0.3476

1.2725

0.0237

0.0296

0.6061

0.3721

Proteins related to oxidative damage / antioxidant potential

AOFA

1.0422

2.0594

 < 0.0001

 < 0.0001

0.2800

0.6953

0.4493

1.3654

0.0018

0.0057

0.9164

0.3684

PRDX3

− 0.0202

0.9861

0.8124

0.8505

0.6295

0.7143

− 0.3877

0.7643

0.0051

0.0009

0.6960

0.5957

PRDX5

− 0.0610

0.9586

0.6122

0.5703

0.6134

0.5220

0.1583

1.1160

0.4753

0.4499

0.6123

0.6325

Protein

AVE LOG FC Control/DCA

ANTILOG AVE FC Control/DCA

p value

2-way RM ANOVA

AVE LOG FC Control/ DM + DCA

ANTILOG AVE FC Control/ DM + DCA

p value

2-way RM ANOVA

Treatment*(DCA)

Run*

Interaction*

Treatment*(DM + DCA)

Run*

Interaction*

Identified proteins involved in the structure and regulation of mPTPs

ADT1

− 0.1289

0.9145

0.1543

0.1649

0.6419

0.8683

− 0.0593

0.9597

0.2917

0.3962

0.8240

0.5683

ADT2

− 0.0821

0.9447

0.4569

0.3953

0.9546

0.5206

0.0020

1.0014

0.9595

0.9613

0.6542

0.7756

AT5F1

− 0.1193

0.9206

0.2490

0.3552

0.1928

0.7669

− 0.1800

0.8827

0.0571

0.0776

0.6004

0.5074

ATP5H

− 0.0905

0.9392

0.2420

0.3562

0.7173

0.1526

− 0.3088

0.8073

0.0064

0.0096

0.5978

0.6334

ATP5I

0.1392

1.1013

0.2832

0.2174

0.6767

0.8986

0.1179

1.0851

0.2934

0.2753

0.7076

0.3013

ATP5L

− 0.4695

0.7222

0.0352

0.0229

0.6399

0.7724

− 0.2791

0.8241

0.0609

0.0539

0.6445

0.6373

ATPA

0.0055

1.0038

0.9605

0.9753

0.5197

0.7277

0.0561

1.0397

0.5275

0.6448

0.8700

0.3218

ATPB

0.0003

1.0002

0.9923

0.9916

0.6250

0.8522

− 0.0628

0.9574

0.3331

0.3623

0.3974

0.5449

ATPD

0.0000

1.0000

1.0000

   

0.0000

1.0000

1.0000

   

ATPG

0.0810

1.0578

0.6574

0.6936

0.5205

0.5839

0.0340

1.0238

0.7786

0.8830

0.8787

0.9464

ATPK

− 0.2049

0.8676

0.2066

0.2421

0.8209

0.9730

− 0.1709

0.8883

0.4839

0.4572

0.9764

0.8514

ATPO

− 0.0378

0.9741

0.5120

0.6362

0.3766

0.6651

− 0.0872

0.9413

0.5505

0.5430

0.3056

0.4994

KCRS

0.2721

1.2076

0.0888

0.0643

0.7394

0.3619

0.2343

1.1764

0.1558

0.1332

0.3824

0.7034

MPCP

0.2172

1.1625

0.0853

0.0857

0.2322

0.8736

− 0.1501

0.9012

0.0904

0.0877

0.0893

0.7103

VDAC1

0.0311

1.0218

0.6414

0.7358

0.4527

0.7970

− 0.0528

0.9641

0.7263

0.6478

0.7021

0.1620

VDAC2

0.1162

1.0839

0.4256

0.3582

0.8843

0.6476

0.1442

1.1051

0.3565

0.2777

0.9006

0.7744

VDAC3

0.3198

1.2481

0.1294

0.2288

0.4864

0.8664

0.4591

1.3747

0.0237

0.0125

0.5940

0.8591

Proteins related to oxidative damage/antioxidant potential

AOFA

− 0.0387

0.9736

0.9632

0.9562

0.7638

0.3912

− 0.5930

0.6630

0.0055

0.0017

0.7748

0.2765

PRDX3

− 0.1513

0.9005

0.1055

0.1438

0.8213

0.4641

− 0.3676

0.7751

0.0026

0.0013

0.9592

0.3221

PRDX5

0.3322

1.2589

0.0458

0.0626

0.4303

0.3470

0.2193

1.1642

0.2173

0.1740

0.9607

0.9352

  1. *p value from testing the hypothesis of no difference in log emPAI values for the indicated sources of variation compared to random variability. FC fold change; AVE average; P: probability; RM repeated measures; AOFA amine oxidase [flavin-containing] A; PRDX3 thioredoxin-dependent peroxide reductase; PRDX5 peroxiredoxin 5. Names and abbreviations of the proteins involved in the structure and regulation of mPTPs are in the legend of Fig. 5.
Back to article page