Table 2 Crude and adjusted risks of myocardial infarction or cerebral infarction according to gallstone-related infection and cholecystectomy.
Gallstones | |||||||||
|---|---|---|---|---|---|---|---|---|---|
All | GSI | Non-GSI | |||||||
aHR (95% CI) | Events/person-time | Rate* (95% CI) | IRR (95% CI) | aHR (95% CI) | Events/person-time | Rate (95% CI) | IRR (95% CI) | aHR (95% CI) | |
Myocardial infarction | |||||||||
Matched control | 5,035/ 5,414,099 | 9.30 (9.05–9.56) | 23,831/26,623,120 | 8.95 (8.84–9.07) | |||||
Without cholecystectomy | 1.10 (1.05–1.15) | 235/180,021 | 13.05 (11.49–14.83) | 1.40 (1.23–1.60) | 1.32 (1.15–1.50) | 1,751/1,785,157 | 9.81 (9.36–10.28) | 1.10 (1.04–1.15) | 1.07 (1.02–1.12) |
With cholecystectomy | 1.10 (1.03–1.16) | 381/356,528 | 10.69 (9.67–11.82) | 1.15 (1.03–1.28) | 1.17 (1.05–1.29) | 767/849,656 | 9.03 (8.41–9.69) | 1.01 (0.94–1.08) | 1.07 (1.00–1.15) |
Risk reduction by cholecystectomy(%)# | 0.0 (-0.9–1.9) | 11.4 (8.7–14.0) | 0.0 (-2.7–2.0) | ||||||
Cerebral infarction | |||||||||
Matched control | 10,656/ 5,392,612 | 19.76 (19.39–20.14) | 48,835/ 26,526,916 | 18.41 (18.25–18.57) | |||||
Without cholecystectomy | 1.08 (1.05–1.12) | 466/179,145 | 26.01 (23.75–28.48) | 1.32 (1.20–1.44) | 1.24 (1.13–1.36) | 3,569/1,778,205 | 20.07 (19.42–20.74) | 1.09 (1.05–1.13) | 1.06 (1.03–1.10) |
With cholecystectomy | 1.02 (0.98–1.06) | 708/355,075 | 19.94 (18.52–21.46) | 1.01 (0.93–1.09) | 1.04 (0.96–1.12) | 1,474/ 846,798 | 17.41 (16.54–18.32) | 0.95 (0.90–1.00) | 1.01 (0.96–1.07) |
Risk reduction by cholecystectomy(%) | 5.6 (5.4–6.7) | 16.1 (15.0–17.6) | 4.7 (2.7–6.8) | ||||||
