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The backbone Cα-RMSD plots reflecting the conformational stabilities of ACE2 (black) and docked complexes with ligands, NF1 (blue), NF12 (red), and NF13 (green). A similar color scheme is used to represent the plots for protein and protein–ligand complexes from Figs. 2, 3, 4, 5, 6 and 7.