Table 2 Differentially expressed genes according to the stromal component of chordomas.
Gene | Description | Fold change | Adjusted p-value |
|---|---|---|---|
Up-regulated genes in stroma-rich chordomas (top 20 genes from total of 50 genes, adjusted p-value < 0.1, Fold change > 2.0) | |||
SFRP2 | Secreted frizzled related protein 2 | 4.59 | < 0.001 |
SERPINE2 | Serpin family E member 2 | 5.30 | 0.004 |
H19 | H19 imprinted maternally expressed transcript | 10.12 | 0.006 |
CMYA5 | Cardiomyopathy associated 5 | 4.35 | 0.007 |
ECMXP | Extracellular matrix protein X-linked, pseudogene | 26.13 | 0.007 |
COMP | Cartilage oligomeric matrix protein | 35.45 | 0.008 |
IGSF9B | Immunoglobulin superfamily member 9B | 3.76 | 0.019 |
PNMA2 | PNMA family member 2 | 2.70 | 0.022 |
LINC00954 | Long intergenic non-protein coding RNA 954 | 2.33 | 0.023 |
ITGA11 | Integrin subunit alpha 11 | 3.56 | 0.024 |
MATN3 | Matrilin 3 | 23.95 | 0.026 |
FST | Follistatin | 6.68 | 0.033 |
ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif 16 | 6.17 | 0.036 |
KCNA6 | Potassium voltage-gated channel subfamily A member 6 | 6.63 | 0.051 |
COCH | Cochlin | 6.48 | 0.052 |
CNMD | Chondromodulin | 13.96 | 0.062 |
WSCD2 | WSC domain containing 2 | 5.30 | 0.063 |
TUBB2B | Tubulin beta 2B class IIb | 4.46 | 0.063 |
SHROOM4 | Shroom family member 4 | 2.10 | 0.063 |
Down-regulated genes in stroma-rich chordomas (adjusted p-value < 0.1, fold change < 0.5) | |||
MT1E | Metallothionein 1E | 0.25 | < 0.001 |
NDRG4 | NDRG family member 4 | 0.34 | 0.001 |
SLC25A16 | Solute carrier family 25 member 16 | 0.50 | 0.019 |
CAMK2D | Calcium/calmodulin dependent protein kinase II delta | 0.39 | 0.058 |
UBE2D1 | Ubiquitin conjugating enzyme E2 D1 | 0.43 | 0.071 |
EXPH5 | Exophilin 5 | 0.32 | 0.093 |
ABCG1 | ATP binding cassette subfamily G member 1 | 0.44 | 0.093 |
