Figure 1
From: A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma
Transcription factor (TF) regulons associated with cell cycle activity. Activity of 121 TF regulons significantly associated with cell cycle activity. Of these, 65 TF regulons associated with high cell cycle and 56 associated with low cell cycle activity. In addition to TFs with a known role in the cell cycle, significant TF regulons include the pluripotency factors SALL4 and SOX2, multiple homeobox factors, and the sex hormone binding receptors ESR1 and PGR. The bar plots demonstrate the correlation between mitotic index and activity of each significant TF regulon, determined using Cohort 1.
