Table 2 Univariate and multivariate Cox analyses on variables for the prediction of overall survival of NM-GBA patients.

From: A novel nomogram based on log odds of positive lymph nodes to predict survival for non-metastatic gallbladder adenocarcinoma after surgery

Variable

Univariate analysis

Ā 

Multivariate analysis

HR (95% CI)

P value

HR (95% CI)

P value

Sex

Female

Reference

Ā Ā Ā Ā 

Male

1.275 (1.055–1.541)

0.012

Ā 

1.414 (1.153–1.735)

 < 0.001

Race

White

Reference

Ā Ā Ā Ā 

Black

0.803 (0.606–1.066)

0.129

Ā 

1.013 (0.757–1.355)

0.933

Other

0.750 (0.563–0.999)

0.049

Ā 

0.963 (0.715–1.298)

0.806

Grade

G1

Reference

Ā Ā Ā Ā 

G2

1.539 (1.155–2.051)

0.003

Ā 

1.320 (0.978–1.780)

0.070

G3

1.982 (1.479–2.657)

 < 0.001

Ā 

1.350 (0.987–1.847)

0.060

G4

3.075 (1.466–6.448)

0.003

Ā 

2.250 (1.056–4.796)

0.036

T

T1

Reference

Ā Ā Ā Ā 

T2

1.286 (0.937–1.764)

0.119

Ā 

0.604 (0.302–1.210)

0.155

T3

2.722 (1.973–3.754)

 < 0.001

Ā 

1.123 (0.559–2.253)

0.745

T4

4.883 (2.901–8.221)

 < 0.001

Ā 

0.944 (0.381–2.339)

0.901

Stage

Stage I

Reference

Ā Ā Ā Ā 

Stage II

1.046 (0.719–1.522)

0.813

Ā 

1.635 (0.740–3.612)

0.224

Stage III

2.781 (1.977–3.913)

 < 0.001

Ā 

2.042 (0.937–4.452)

0.072

Stage IV

4.855 (3.092–7.622)

 < 0.001

Ā 

4.271 (1.745–10.453)

0.001

Radiation

None

Reference

Ā Ā Ā Ā 

Yes

0.960 (0.788–1.169)

0.684

Ā 

0.813 (0.636–1.039)

0.098

Chemotherapy

None

Reference

Ā Ā Ā Ā 

Yes

0.954 (0.798–1.141)

0.605

Ā 

0.770 (0.606–0.979)

0.033

LODDS

LODDS1

Reference

Ā Ā Ā Ā 

LODDS2

1.899 (1.511–2.387)

 < 0.001

Ā 

1.792 (1.405–2.286)

 < 0.001

LODDS3

4.244 (3.313–5.436)

 < 0.001

Ā 

3.221 (2.373–4.371)

 < 0.001

Size (mm)

1–13

Reference

Ā Ā Ā Ā 

14–56

2.040 (1.521–2.737)

 < 0.001

Ā 

1.487 (1.091–2.028)

0.012

57–160

3.446 (2.412–4.923)

 < 0.001

Ā 

2.254 (1.540–3.297)

 < 0.001

Age (years)

29–72

Reference

Ā Ā Ā Ā 

73–82

1.712 (1.402–2.090)

 < 0.001

Ā 

1.601 (1.289–1.988)

 < 0.001

83–100

2.630 (2.043–3.384)

 < 0.001

Ā 

1.908 (1.421–2.562)

 < 0.001

Marital

Married

Reference

Ā Ā Ā Ā 

Single

0.954 (0.721–1.263)

0.744

Ā 

1.193 (0.889–1.599)

0.240

Separated

1.000 (0.751–1.331)

0.997

Ā 

1.055 (0.778–1.429)

0.731

Widowed

1.498 (1.208–1.858)

 < 0.001

Ā 

1.222 (0.958–1.558)

0.106

  1. HR hazard ratio, CI confidence interval, LODDS log odds of positive lymph nodes.