Table 3 NRI, IDI, C-index, and AUC of the nomogram and the AJCC 8th edition TNM-staging system in survival prediction for NM-GBA patients.
Index | Training cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|
Estimate | 95% CI | P value | Estimate | 95% CI | P value | |
NRI (vs. stage) | ||||||
1-year OS | 0.648 | 0.532ā0.862 | Ā | 0.714 | 0.411ā0.950 | Ā |
3-year OS | 0.625 | 0.480ā0.757 | Ā | 0.495 | 0.343ā0.791 | Ā |
5-year OS | 0.589 | 0.434ā0.739 | Ā | 0.486 | 0.301ā0.799 | Ā |
IDI (vs. stage) | ||||||
1-year OS | 0.073 | 0.058ā0.088 | ā<ā0.001 | 0.078 | 0.054ā0.102 | ā<ā0.001 |
3-year OS | 0.102 | 0.072ā0.132 | ā<ā0.001 | 0.102 | 0.073ā0.131 | ā<ā0.001 |
5-year OS | 0.099 | 0.081ā0.117 | ā<ā0.001 | 0.097 | 0.068ā0.126 | ā<ā0.001 |
C-index | ||||||
Nomogram | 0.730 | 0.708ā0.752 | Ā | 0.746 | 0.717ā0.775 | Ā |
AJCC stage | 0.639 | 0.617ā0.661 | Ā | 0.660 | 0.631ā0.689 | Ā |
Change | 0.191 | 0.169ā0.213 | ā<ā0.001 | 0.186 | 0.157ā0.215 | ā<ā0.001 |
AUC | ||||||
Nomogram 1 Y | 0.802 | 0.766ā0.838 | Ā | 0.784 | 0.749ā0.819 | Ā |
AJCC stage 1 Y | 0.666 | 0.629ā0.704 | Ā | 0.694 | 0.645ā0.744 | Ā |
Nomogram 3 Y | 0.803 | 0.770ā0.835 | Ā | 0.784 | 0.751ā0.817 | Ā |
AJCC stage 3 Y | 0.704 | 0.669ā0.739 | Ā | 0.741 | 0.690ā0.792 | Ā |
Nomogram 5 Y | 0.794 | 0.756ā0.832 | Ā | 0.786 | 0.751ā0.821 | Ā |
AJCC stage 5 Y | 0.701 | 0.660ā0.742 | Ā | 0.742 | 0.682ā0.802 | Ā |