Table 1 Amiodarone treatment of SCD mice improved circulating RBC parameters.

From: Amiodarone improves anemia in a murine model of sickle cell disease and is associated with increased erythrocyte bis(monoacylglycerol) phosphate

Treatment (N)

RBC (M/uL)

HB (g/dL)

HCT (%)

Ret (%)

Sickle (%)

PBS (4)

7.88 ± 0.36

9.45 ± 0.48

38.00 ± 2.70

25.19 ± 3.87

54.54 ± 8.19

Amio (5)

8.08 ± 0.27

10.38 ± 0.43

41.25 ± 1.07

19.94 ± 1.17

25.46 ± 7.30

p value

0.046

0.0003

0.031

0.0366

0.012

  1. Mice were given Amiodarone (10 mg/kg) or vehicle (PBS) via intraperitoneal injection daily for 2 weeks. Mean ± standard deviation listed, significance determined by student’s t-test (p < 0.05).
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