Table 3 Selectivity index (SI) of series (A), (B) and AAZ toward tumor related hCA IX & XII over the off-target hCA I & II.

From: Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX

Compound*

Selectivity index (SI)

I/IX

II/IX

I/XII

II/XII

5a

6.7

6.8

0.3

0.2

6a

0.6

0.8

0.1

0.2

6b

0.4

0.8

0.1

0.2

6c

0.1

0.1

0.02

0.04

7a

23.2

1.3

1.5

0.1

8a

0.1

2.5

0.01

0.5

8b

0.2

1.4

0.1

0.6

8c

0.3

0.5

0.4

0.6

10

0.03

0.02

0.01

0.006

12a

2.3

0.3

0.4

0.05

12b

2.5

2

0.3

0.2

12c

0.7

1.4

0.1

0.2

12d

3

2

3

2

12e

4

1

0.5

0.1

12f.

3

2.5

0.1

0.1

12g

0.8

3.6

0.07

0.3

12h

9.7

6.1

5.8

3.6

12i

12.4

6.5

2.6

1.4

12j

5.5

4.1

5.9

4.3

AAZ

9.7

0.5

43.9

2.1

  1. *Compounds with Ki < 10,000 aren’t shown.
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