Table 4 Calculated GI% for target compounds, in series (A) and (B) at (10−5 M) concentration, concerning the most sensitive NCI cancer cell lines.

From: Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX

Compounda

Subpanel/cell line

CNS cancer (SNB-75)

Renal cancer (UO-31)

Breast cancer (MDA-MB-468)

Leukemia (SR)

5a

29

–

–

–

5b

28

11

–

–

5c

35

11

–

–

6a

–

19

18

13

6b

28

–

–

–

6c

21

16

–

–

6d

30

12

–

–

6e

–

11

–

–

6f.

23

11

–

–

6g

33

14

–

–

6h

–

17

–

–

6i

–

14

–

–

6j

29

17

–

–

7a

–

12

–

–

8a

14

17

–

–

8b

21

–

11

15

8c

–

–

–

–

10

33

–

–

–

12a

–

–

–

–

12b

14

16

16

14

12c

–

14

22

16

12d

12

14

62

51

12e

–

13

27

11

12f.

10

15

15

11

12g

15

11

11

–

12h

–

–

11

27

12i

–

20

17

–

12j

11

14

–

–

  1. aOnly GI% ≥ 10% are shown.
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