Figure 2
From: Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells
Gene set enrichment analysis of drug targets in combinatorial screen. GSEA enrichment plots provide the distribution of the enrichment score (green line) across compounds annotated to molecular targets (vertical black line), ranked in order of antiviral activity (left to right). The enrichment score (ES) reflects the degree to which a gene set is overrepresented at the top of a ranked list of compounds interacting with the given target. GSEA calculates the ES by walking down the ranked list of compounds interacting with the given target, increasing a running-sum statistic when a gene is in the gene set and decreasing it when it is not. Glucocorticoid receptor (p = 0.0001; FDR q value = 0.013), Calcium Channel (p = 0.004; FDR q value = 0.086), Proton pump (p = 0.003; FDR q value = 0.085) and HIV protease (p = 0.007; FDR q value = 0.095) are identified as targets enriched in the hitlist for the synergy screen in background of EC15 of remdesivir.
