Figure 4 | Scientific Reports

Figure 4

From: Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity

Figure 4

N-3 PUFA enriched diet decreases ceramides and sphingomyelins in lungs and blood cells. Sphingolipids in lung (a–f) and whole blood (g–l) from BALB/c mice that were fed either FO or CO diet for 8 weeks. (a, g) Long chain bases. (b, h) Ratios of the two phosphorylated long chain bases sphingosine-1P (S1P) and sphinganine-1P (Sa1P) to sphinganine and sphingosine. (c, i) Dihydroceramides. (d, j) Ceramides. (e, k) Sphingomyelins. (f, l) Glucosylceramides. Data are representative of 3 independent experiments with 5–6 mice per group. *p < 0.05. **p < 0.001, ***p < 0.0001, ****p < 0.00001 (two-way ANOVA with Tukey’s multiple comparisons test).

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