Figure 2
From: Metagenomic DNA sequencing to quantify Mycobacterium tuberculosis DNA and diagnose tuberculosis
(A) The fragment length distributions of M. tuberculosis DNA in plasma (red) and urine (blue). (B) The fragment length distribution of M. tuberculosis DNA (purple) and host chromosomal DNA (green) in oral swabs are similar, suggesting that the microbial DNA is genomic and the fragmentation profile is not an intrinsic property but rather the consequence of sample preparation steps. (C) The abundance of M. tuberculosis DNA across all cohorts and biofluids. The majority of non-endemic samples have little to no detectable M. tuberculosis DNA, while the abundance of M. tuberculosis DNA in endemic and tuberculosis samples increases from plasma to oral swab. Dashed line indicates a limit of detection cutoff of 0.1 RPM.
