Figure 3
From: Metagenomic DNA sequencing to quantify Mycobacterium tuberculosis DNA and diagnose tuberculosis
The performance of the metagenomic assay in discriminating (A) sputum positive versus sputum negative samples, (B) tuberculosis versus endemic cohorts, and (C) tuberculosis versus non-endemic cohorts (AUC = area under the curve). (D) Evaluating the effects of incorporating non-endemic samples (blue) and endemic samples (red) on the diagnostic performance via simulation show that the inclusion of non-endemic samples skews the assay’s sensitivity.
