Table 3 Factors associated with LD.

	Unadjusted univariate analysis		Adjusted multivariate analysis^a
	OR (95% CI)	P-value	OR (95% CI)	P-value
Age (years)	1.00 (0.977–1.022)	0.977	-
Male	0.88 (0.516–1.484)	0.620	–
Hypertension	0.94 (0.523–1.775)	0.906
Diabetes mellitus	0.54 (0.301–0.949)	0.033
Hyperlipidemia	0.61 (0.358–1.037)	0.068	0.31 (0.143–0.651)	0.002
Smoking history	0.75 (0.435–1.299)	0.307
Previous stroke history	1.03 (0.565–1.888)	0.917
Previous antiplatelet	1.18 (0.523–2.640)	0.696
Previous statin	2.29 (0.901–5.798)	0.082	4.35 (1.175–16.114)	0.028
Initial NIHSS	0.85 (0.761–0.941)	0.002	0.78 (0.679–0.895)	< 0.001
White matter hyperintensities
0–1	1 (reference)		1 (reference)
2–3	1.93 (1.089–3.404)	0.024	2.06 (0.960–4.406)	0.064
Microbleeds	1.62 (0.908–2.896)	0.103
Lacunes	1.59 (0.927–2.741)	0.092
Location
APA	1 (reference)		1 (reference)
LSA	11.54 (5.951–22.372)	< 0.001	11.07 (5.007–24.470)	< 0.001
Stenosis degree
No stenosis	1 (reference)
< 50% stenosis	0.45 (0.259–0.786)	0.005
MCA or BA shape
Straight	1 (reference)		1 (reference)
U or C shape	0.65 (0.336–1.265)	0.206	0.86 (0.360–2.035)	0.726
S shape	3.51 (1.486–8.265)	0.004	3.51 (1.486–8.265)	0.004

Results are presented by OR (95% CI).
LSA: Lenticulostriate arteries, APA: Anterior pontine arteries, MCA: middle cerebral artery, BA: basilar artery, LD: lipohyalinotic degeneration; NIHSS: National Institutes of Health Stroke Scale.
^aMultivariate logistic regression adjusted for age, sex, initial NIHSS, Diabetes mellitus, Hyperlipidemia, Previous statin, location, stenosis degree and MCA or BA shape.

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