Figure 1
From: Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy
Decreased NKCC1 and AQP5 expressions are associated with salivary gland hypofunction in SjD patients. (A) Individuals who visited a rheumatology clinic because of sicca symptoms underwent labial minor salivary glands (MSGs) biopsy, measurement of salivary flow rate (SFR) and serum anti-Ro/SSA antibody tests. Thereafter, participants were divided into two groups: SjD patients with decreased SFR (n = 5) and control subjects with normal SFR (n = 6). (B) Representative immunofluorescent images of MSGs indicating staining for NKCC1 or AQP5 (green) and dot plots showing mean fluorescent intensity (MFI) of NKCC1 or AQP5 staining in each MSG (scale bars = 50 µm). Values shown are mean ± SD. *P < 0.05, **P < 0.01 (Student’s t-tests).
