Table 2 Top results of integrative enrichment analysis with IPA.

Abnormality of cerebral cortex

8.3E−5

 − 1.951

Glutamate*

CD81, CELSR3, CYGB, F12, TNR*

VIM*

Apoptosis

6.1E−5

 − 1.458

O-acetyl carnitine*, alpha-tocopherol*, choline, ethanolamine*, glycine*, glutamate*, glutamine*, ethanolamine phosphate*, S-adenosylmethionine*

B2M, CYGB, GHRH, HAPLN1*, IFIT3, ISG15, MTSS1*, PCP4*, SERPINB9, SPP1, STAR, VCAN

ADAM10*, EIF4B*, HNRNPC*, MAP2K4, PPP1R2*, SPP1*, UBE2V2*, VIM*, ZFP36L1

Synthesis of protein

1.9E−7

 − 1.315

Creatine*, glycine*, aspartate*, glutamate*

IGFBP2, ISG15, SPP1

EEF2*, EIF4B*, LARP1, MAP2K4, PPP1R2*, SPP1*, VIM*, ZFP36L1

Metabolism of protein

7.9E−08

 − 0.781

Creatine*, glycine*, aspartate*, glutamate*

B2M, CD81, F12, F9, IGFBP2, ISG15, SPP1, VCAN

ADAM10*, EEF2*, EIF4B*, LARP1, LONP1*, MAP2K4, PPP1R2*, SPP1*, VIM*, ZFP36L1

Synthesis of amino acids

4.4E−5

 − 0.555

Creatine*, glycine*, aspartate*, glutamate*

VCAN

Transmembrane potential of mitochondria

7.4E−5

0.958

Glutamate*, S-adenosylmethionine*

B2M, STAR

LONP1*, MAP2K4, VIM*

Conversion of lipid

2.0E−7

1.476

O-acetyl carnitine*, alpha-tocopherol*, creatine*, glycine*, guanidoacetic acid*, glutamate*, glutamine*, S-adenosylmethionine*

CYGB, STAR

Peroxidation of lipid

2.6E−08

1.82

O-acetyl carnitine*, alpha-tocopherol*, creatine*, glycine*, guanidoacetic acid*, glutamate*, glutamine*, S-adenosylmethionine*

CYGB

Uptake of amino acids

6.5E−6

2.173

Choline, glycine*, guanidoacetic acid*, aspartate*, glutamate*

TNR*

Progressive neurological disorder

6.0E−6

2.186

O-acetyl carnitine*, choline, creatine*, glutamate*, N-acetylaspartic acid*, S-adenosylmethionine*, glycerophosphocholine*

CHCHD2, F12, IGFBP2, ISG15, SPP1, STAR, TNR*

ADAM10*, EEF2*, SPP1*, VIM*, ZFP36L1