Figure 1 | Scientific Reports

Figure 1

From: Investigating the role of common and rare variants in multiplex multiple sclerosis families reveals an increased burden of common risk variation

Figure 1

Simplified pedigrees of MS families included in the study. Males are represented by squares and females by circles. Diagonal line, deceased individual; red-colored symbol, clinically and magnetic resonance imaging-proven MS case; open symbol, non-MS relative. Individuals for whom SNP genotyping or exome sequencing was done are indicated with “SNP” and “WES,” respectively. Double line indicates consanguineous marriage, and relatedness degrees between these individuals are shown as PI-HAT values. PI-HAT for FMS0121 and FMS0132 was calculated using PLINK. Values for other consanguineous couples indicate the expected PI-HAT values based on the reported family relationships by the study participants. Pedigrees were constructed using the genetic data management system, Progeny Clinical—Web Version 9 from Progeny Genetics (Copyright 2019. Reprinted with permission of Progeny Genetics LLC, Delray Beach, FL, www.progenygenetics.com). NA, not applicable; PPMS, primary progressive MS; RRMS, relapsing–remitting MS; SPMS, secondary progressive MS.

Back to article page