Table 2 Association of polygenic risk scores and weighted sum scores with risk of MS.

From: Investigating the role of common and rare variants in multiplex multiple sclerosis families reveals an increased burden of common risk variation

Genetic risk score

Comparison

OR

Lower CI

Higher CI

Adjusted P value

Polygenic risk score

Familial MS cases versus Population controls

1.84

1.277

2.63

0.0077*

Familial MS cases versus Control families

2.27

1.323

4.318

0.0491*

Familial MS cases versus Unaffected relatives

2.61

1.322

6.085

0.1053

Sporadic MS cases versus Familial MS cases

1.83

1.11

3.7

0.087

Weighted sum score

Familial MS cases versus Population controls

2.16

1.439

3.279

0.002*

Familial MS cases versus Control families

2.4

1.447

4.327

0.014*

Familial MS cases versus Unaffected relatives

1.64

0.909

3.16

1

Sporadic MS cases versus Familial MS cases

0.82

0.45

1.44

0.95

Weighted sum score (non-MHC)

Familial MS cases versus Population controls

1.83

1.222

2.771

0.0324*

Familial MS cases versus Control families

1.92

1.193

3.276

0.0972

Familial MS cases versus Unaffected relatives

1.4

0.793

2.613

1

Sporadic MS cases versus Familial MS cases

0.81

0.45

1.4

0.93

  1. OR, odds ratio (95% confidence intervals [CI]); Adjusted P value, after Bonferroni correction; *, significant.
Back to article page